BACK

Now that you and your doctor have chosen Opdualag as your immunotherapy treatment, it’s time to set yourself up with information and support to help you make the most of it.
Use the resources in this online learning center to get started.

STEP 1WATCH AND
LEARN

Look through the 4 sections below with your family or a friend.

STEP 2 REVIEW AND
SHARE

Then, download a summary sheet to go over with your doctor.

STEP 1WATCH AND LEARN

Click to watchplay button
 
Video length: 01:54

Please see
Important Safety Information.

SECTION 1 OF 4

CANCER AND YOUR IMMUNE SYSTEM

Watch this video to learn how your immune system helps your body defend itself against cancer.

Continue watching this video Learning about the immune system will give you a strong start toward understanding how immunotherapy may work.

Now that you've completed this
video, remember: T cells in your immune system normally search for and attack threats like cancer. Now, take a look at the next section to learn how Opdualag may work with these cells.

STEP 1WATCH AND LEARN

SECTION 1 OF 4

CANCER AND YOUR IMMUNE SYSTEM

Video length: 01:59
Click to watch play button
 

Please see Important Safety Information.

Watch this video to learn how your immune system helps your body defend itself against cancer.

Continue watching this video Learning about the immune system will give you a strong start toward understanding how immunotherapy may work.

Now that you've completed this
video, remember: T cells in your immune system normally search for and attack threats like cancer. Now, take a look at the next section to learn how Opdualag may work with these cells.

SECTION 2 OF 4

HOW OPDUALAG IMMUNOTHERAPY WORKS

Opdualag may help energize your immune system with 2 immunotherapies in 1 medicine.

Opdualag can cause your T cells to attack healthy cells contained within organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death, and may happen anytime during treatment or even after treatment has ended. You may have more than one of these problems at the same time. Your doctor will check for these problems during treatment.

SELECT IMPORTANT FACTS ABOUT OPDUALAG

Opdualag can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include: lung problems; intestinal problems; liver problems; hormone gland problems; kidney problems; skin problems; problems in other organs and tissues; severe infusion reactions; and complications of stem cell transplant that uses donor stem cells (allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms.

SECTION 2 OF 4

HOW OPDUALAG IMMUNOTHERAPY WORKS

Opdualag may help energize your immune system with 2 immunotherapies in 1 medicine.

This is a general example of how Opdualag works. Each patient is different and clinical results may vary.

Opdualag can cause your T cells to attack healthy cells contained within organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death, and may happen anytime during treatment or even after treatment has ended. You may have more than one of these problems at the same time. Your doctor will check for these problems during treatment.

SELECT IMPORTANT FACTS ABOUT OPDUALAG

Opdualag can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include: lung problems; intestinal problems; liver problems; hormone gland problems; kidney problems; skin problems; problems in other organs and tissues; severe infusion reactions; and complications of stem cell transplant that uses donor stem cells (allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms.

I tell my doctor if something seems
unusual. She’ll help me figure out if
that could be a side effect.

– Actor portrayal
SECTION 3 OF 4

SIDE EFFECTS TO LOOK OUT
FOR AND WHAT TO DO

Learn how to play an active role in identifying
and reporting side effects. After all, there may
be signs that only you can notice.

Please see Important Safety Information.

IT’S IMPORTANT TO NOTICE ANY CHANGES IN YOUR BODY AFTER YOU BEGIN TREATMENT AND TO REPORT THEM TO YOUR HEALTHCARE TEAM RIGHT AWAY.

If you are taking Opdualag in combination with another medicine, consult your healthcare professional about the potential side effects of that medicine.

Select each body part to learn what to look for.

Discuss the most common side effects of Opdualag with your doctor. These include: feeling tired; pain in muscles, bones, and joints; rash; itchy skin; back pain; and diarrhea. There may also be serious side effects, including complications of stem cell transplant that uses donor stem cells (allogeneic). These are not all of the possible side effects of Opdualag. This is why you need to report any discomfort or changes in the way you are feeling to your Oncology Care Team.

KNOWING THE ANSWERS TO THESE QUESTIONS CAN HELP

SECTION 3 OF 4

SIDE EFFECTS TO LOOK OUT
FOR AND WHAT TO DO

Learn how to play an active role in identifying and reporting side effects. After all, there may
be signs that only you can notice.

Please see Important Safety Information.

I tell my doctor if something seems
unusual. She’ll help me figure out if
that could be a side effect.

– Actor portrayal

IT’S IMPORTANT TO NOTICE ANY CHANGES IN YOUR BODY AFTER YOU BEGIN TREATMENT AND
TO REPORT THEM TO YOUR HEALTHCARE TEAM RIGHT AWAY.

If you are taking Opdualag in combination with another medicine, consult your healthcare professional about the potential side effects of that medicine.

Select each body part to learn what to look for.

Discuss the most common side effects of Opdualag with your doctor. These include: feeling tired; pain in muscles, bones, and joints; rash; itchy skin; back pain; and diarrhea. There may also be serious side effects, including complications of stem cell transplant that uses donor stem cells (allogeneic). These are not all of the possible side effects of Opdualag. This is why you need to report any discomfort or changes in the way you are feeling to your Oncology Care Team.

KNOWING THE ANSWERS TO THESE QUESTIONS CAN HELP

Click to watchplay button
 
Video length: 01:28

Please see
Important Safety Information.

SECTION 4 OF 4

HOW YOUR SUPPORT TEAM CAN HELP

Who's on your support team? Watch this video to find out who they can be—and how they can help.

Continue watching this video Learn how people can help you along
the way.

Now that you've completed this
video, remember: You are not alone. Keep your support
team involved and informed so they can
help you throughout your treatment.

What helped me a lot was sharing my experiences with others who were going through the same thing.

– Actor portrayal
SECTION 4 OF 4

HOW YOUR SUPPORT TEAM CAN HELP

Video length: 01:50
Click to watch play button
 

Please see Important Safety Information.

Who's on your support team? Watch this video to find out who they can be—and how they can help.

Continue watching this video Learn how people can help you along
the way.

Now that you've completed this
video, remember: You are not alone. Keep your support
team involved and informed so they can
help you throughout your treatment.

What helped me a lot was sharing my experiences with others who were going through the same thing.

– Actor portrayal

STEP 2REVIEW AND SHARE

Get a completion certificate with a quick
summary of what you've learned. Review the information with your doctor during
your next appointment.

GET IT NOW
PATIENT RESOURCE LIBRARY

Click below to download and print materials to use
while you're on treatment.

SIGN UP FOR INFORMATION AND SUPPORT

Get support, tools, and
educational resources.

SELECT IMPORTANT FACTS ABOUT OPDUALAG™

Opdualag can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include lung problems; intestinal problems; liver problems; hormone gland problems; kidney problems; skin problems; problems in other organs and tissues; severe infusion reactions; and complications of stem cell transplant that uses donor stem cells (allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms.

Important Facts About Opdualag™ (nivolumab and relatlimab-rmbw)

This is a summary of important information that you need to know about Opdualag. Your healthcare team can work with you to help answer any questions you may have about this medication. Keep this information in a safe place so you can refer to it before and during your treatment.

  • Look out for the following icons as you read:
  • Talk to your
    healthcare team
  • Call a healthcare
    provider right away
  • Helpful information
    to remember

What is Opdualag?

Opdualag is a premixed combination of nivolumab and relatlimab that is prepared and given through intravenous (IV) infusions. Opdualag is a prescription medicine used to treat:

Adults who have a type of skin cancer called melanoma that has spread or cannot be removed by surgery (advanced melanoma).

Children who are 12 years of age and older, who have melanoma that has spread or cannot be removed by surgery (advanced melanoma).

It is not known if Opdualag is safe and effective when used in children younger than 12 years of age or in children 12 years and older weighing less than 88 pounds (40 kg) or for the treatment of any other cancers.

An IV infusion is when medicine is given directly into the bloodstream through a needle placed in a vein by a healthcare professional – usually in the arm or hand.

What is the most important information I should know about Opdualag?

Opdualag can cause serious side effects any time during and after treatment. A serious side effect is a side effect that can sometimes become life-threatening and can lead to death. Serious side effects may happen anytime during treatment or even after your treatment has ended. You may experience more than one side effect at the same time.

Get medical help right away if you develop any new symptoms or if they get worse. It may keep these problems from becoming more serious. Your healthcare team will check you for side effects during treatment, and may treat you with corticosteroid or hormone replacement medicines. If you have severe side effects, your healthcare team may need to delay or completely stop your treatment.

Immune system-related side effects

Opdualag is a medicine that may treat melanoma that has spread or cannot be removed by surgery by working with your immune system. Opdualag can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. Some of these problems can sometimes become severe and can lead to death.

This is a list of some possible immune system-related side effects of Opdualag. You may experience other side effects that are not listed. You may experience side effects anytime during treatment, or even after treatment has ended.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

Lung problems – Things to look out for may include:

  • new or worsening cough
  • shortness of breath
  • chest pain

Intestinal problems – Things to look out for may include:

  • diarrhea (loose stools) or more
    frequent bowel movements than usual
  • stools that are black, tarry,
    sticky, or have blood or mucus
  • severe stomach-area (abdominal)
    pain or tenderness

Liver problems – Things to look out for may include:

  • yellowing of your skin or
    the whites of your eyes
  • severe nausea or vomiting
  • pain on the right side of your
    stomach area (abdomen)
  • dark urine (tea colored)
  • bleeding or bruising more easily
    than normal

Hormone gland problems – Things to look out for may include:

  • headaches that will not go away
    or unusual headaches
  • eye sensitivity to light
  • eye problems
  • rapid heartbeat
  • increased sweating
  • extreme tiredness
  • weight gain or weight loss
  • feeling more hungry or thirsty than usual
  • urinating more often than usual
  • hair loss
  • feeling cold
  • constipation
  • your voice gets deeper
  • dizziness or fainting
  • changes in mood or behavior,
    such as decreased sex drive,
    irritability, or forgetfulness

Kidney problems – Things to look out for may include:

  • decrease in the amount of urine
  • blood in your urine
  • swelling in your ankles
  • loss of appetite

Skin problems – Things to look out for may include:

  • rash
  • itching
  • skin blistering or peeling
  • painful sores or ulcers in the mouth,
    nose, throat or genital area

Heart problems – Things to look out for may include:

  • new or worse chest pain
  • irregular heartbeat or feel like your heart is racing
  • shortness of breath
  • tiredness
  • swelling in your ankles

Immune system-related side effects can also happen in other organs and tissues with Opdualag™ (nivolumab and relatlimab-rmbw), including:

Brain and nerve problems – Things to look out for may include:

  • confusion
  • sleepiness
  • memory problems
  • changes in mood or behavior
  • stiff neck
  • balance problems
  • tingling or numbness of the arms or legs

Eye or vision problems – Things to look out for may include:

  • double vision
  • blurry vision
  • sensitivity to light
  • eye pain
  • changes in eyesight

Muscle problems – Things to look out for may include:

  • persistent or severe muscle pain or weakness
  • muscle cramps

Blood problems – Things to look out for may include:

  • low red blood cells
  • bruising

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms.

What are some other serious side effects of Opdualag?

Severe Infusion Reactions

Opdualag™ (nivolumab and relatlimab-rmbw) is given through intravenous (IV) infusions. The medicine is put directly into your bloodstream through a needle that a healthcare professional places in a vein, usually in your arm or hand.

Things to look out for during an infusion of Opdualag may include:

  • chills or shaking
  • itching or rash
  • flushing
  • shortness of breath
  • dizziness
  • feeling like passing out
  • fever
  • back or neck pain

Tell your healthcare team right away if you get these symptoms during or after an infusion of Opdualag.

Stem Cell Transplant Complications

You may experience complications if you receive donor stem cells (allogeneic stem cell transplant) before or after treatment with Opdualag. These complications can be severe and can lead to death. Your healthcare team will monitor you for signs of complications if you have an allogeneic stem cell transplant.

What are the most common side effects?

The most common side effects of Opdualag include:

  • muscle and bone pain
  • tiredness
  • decreased red blood cell and white blood cell counts
  • increased liver function test results
  • rash
  • itching
  • diarrhea
  • decreased salt (sodium) in your blood

These are not all the possible side effects.

Talk to your healthcare team for more information. You are encouraged to report side effects of prescription drugs to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.

What should I discuss with my healthcare team about pregnancy, birth control, and breastfeeding?

Talk to your healthcare team if:

You are pregnant or plan to become pregnant – Opdualag can harm your unborn baby

If you are able to become pregnant, your healthcare team should do a pregnancy test before you start receiving Opdualag. You should use an effective method of birth control during treatment and for at least 5 months after your last dose of Opdualag.

Talk to your healthcare team about birth control methods that you can use during this time.

Tell your healthcare team right away if you become pregnant or think you are pregnant during treatment with Opdualag.

You are breastfeeding or plan to breastfeed

It is not known if Opdualag passes into your breast milk. Do not breastfeed during treatment with Opdualag and for 5 months after the last dose of Opdualag.

What should I discuss with my healthcare team before starting treatment?

Talk to your healthcare team about all your health problems or concerns, including if you:

  • have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • have had an organ transplant
  • have had or plan to have a stem cell transplant that uses donor stem cells (allogeneic)
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome

Tell your healthcare team about all the medicines you take, including:

  • prescription medicines
  • over-the-counter medicines
  • vitamins
  • herbal supplements

These are not all the topics you should discuss with your healthcare team. Ask your healthcare team about anything you may be unsure about before starting treatment.

How will I receive Opdualag?

Opdualag is a premixed prescription medication (12 mg/mL nivolumab and 4 mg/mL relatlimab) that is prepared and given as intravenous (IV) infusions by your healthcare team.

An IV infusion is when medicine is given directly into the bloodstream through a needle placed in a vein by a healthcare professional – usually in the arm or hand.

Dosage:

Talk to your healthcare team to learn more about the dosing for Opdualag.

Receiving Opdualag:

IV infusion time is about 30 minutes, though actual time in clinic or place of infusion may vary.

Opdualag is usually given every 4 weeks. Your healthcare provider will decide how many treatments you will receive and do blood tests to monitor your health and check for side effects.

Call your healthcare team as soon as possible to reschedule if you miss any of your appointments.

For more information, please see U.S. Full Prescribing Information and Medication Guide for Opdualag.

Talk to your healthcare team for more information about this medication.

Information provided on this website is not a substitute for talking with your healthcare professional.
Your healthcare professional is the best source of information about your disease.

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