BACK

Now that you and your doctor have chosen OPDIVO as your immunotherapy treatment, it’s time to set
yourself up with information and support to help you make the most of it. Use the resources in this
online learning center to get started.

STEP 1WATCH AND
LEARN

Look through the 4 sections below with your family or a friend.

STEP 2 REVIEW AND
SHARE

Then, download a summary sheet to go over with your doctor.

STEP 1WATCH AND LEARN

Click to watchplay button
 
Video length: 01:59

Please see
Important Safety Information.

SECTION 1 OF 4

CANCER AND YOUR IMMUNE SYSTEM

Watch this video to learn how your immune system helps your body defend itself against cancer.

Continue watching this video Learning about the immune system will
give you a strong start toward
understanding how immunotherapy may
work.

Now that you've completed this
video, remember: T cells in your immune system normally
search for and attack threats like cancer.
Now, watch the next video to learn how
OPDIVO may work with these cells.

STEP 1WATCH AND LEARN

SECTION 1 OF 4

CANCER AND YOUR IMMUNE SYSTEM

Video length: 01:59
Click to watch play button
 

Please see Important Safety Information.

Watch this video to learn how your immune system helps your body defend itself against cancer.

Continue watching this video Learning about the immune system will give
you a strong start toward understanding
how immunotherapy may work.

Now that you've completed this
video, remember: T cells in your immune system normally
search for and attack threats like cancer.
Now, watch the next video to learn how
OPDIVO may work with these cells.

Click to watchplay button
 
Video length: 01:13

Please see
Important Safety Information.

SECTION 2 OF 4

HOW OPDIVO
IMMUNOTHERAPY WORKS

Watch this video to see how OPDIVO may work with your immune system to help fight cancer.

Continue watching this video Learn how OPDIVO may work to help
fight cancer.

Now that you've completed this
video, remember: OPDIVO works with your immune system
to help fight cancer. Now, you’re ready to
move on to the next section to learn about
side effects.

OPDIVO can cause your T cells to attack healthy cells contained within organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death and may happen anytime during treatment or even after your treatment has ended.

SELECT IMPORTANT FACTS ABOUT OPDIVO

OPDIVO can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include lung problems; intestinal problems; liver problems; hormone gland problems; kidney problems; skin problems; problems in other organs and tissues; severe infusion reactions; and complications of stem cell transplant that uses donor stem cells (allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms.

SECTION 2 OF 4

HOW OPDIVO
IMMUNOTHERAPY WORKS

Video length: 01:13
Click to watch
 

Please see Important Safety Information.

Watch this video to see how OPDIVO may work with your immune system to help fight cancer.

Continue watching this video Learn how OPDIVO may work to help fight cancer.

Now that you've completed this
video, remember: OPDIVO works with your immune system
to help fight cancer. Now, you’re ready to
move on to the next section to learn about
side effects.

OPDIVO can cause your T cells to attack healthy cells contained within organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death and may happen anytime during treatment or even after your treatment has ended.

SELECT IMPORTANT FACTS ABOUT OPDIVO

OPDIVO can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include lung problems; intestinal problems; liver problems; hormone gland problems; kidney problems; skin problems; problems in other organs and tissues; severe infusion reactions; and complications of stem cell transplant that uses donor stem cells (allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms.

Instead of wondering is that a side
effect or not, I get in touch with
my doctor and discuss it.

– Actor portrayal
SECTION 3 OF 4

SIDE EFFECTS TO LOOK OUT
FOR AND WHAT TO DO

Learn how to play an active role in identifying
and reporting side effects. After all, there may
be signs that only you can notice.

 

Please see Important Safety Information.

IT’S IMPORTANT TO NOTICE ANY CHANGES IN YOUR BODY AFTER YOU BEGIN TREATMENT AND
TO REPORT THEM TO YOUR HEALTHCARE TEAM RIGHT AWAY.

If you are taking OPDIVO in combination with another medicine, consult your healthcare
professional about the potential side effects of that medicine.

Select each body part to learn what to look for.

Discuss the most common side effects of OPDIVO with your doctor. These include: feeling tired; rash; pain in muscles, bones, and joints; itchy skin; diarrhea; nausea; weakness; cough; vomiting; shortness of breath; constipation; decreased appetite; back pain; upper respiratory tract infection; fever; headache; stomach-area (abdominal) pain; and urinary tract infection. There may also be serious side effects, including complications of stem cell transplant that uses donor stem cells (allogeneic). These are not all of the possible side effects of OPDIVO. This is why you need to report any discomfort or changes in the way you are feeling to your Oncology Care Team.

KNOWING THE ANSWERS TO THESE QUESTIONS CAN HELP

SECTION 3 OF 4

SIDE EFFECTS TO LOOK OUT
FOR AND WHAT TO DO

Learn how to play an active role in identifying and reporting side effects. After all, there may
be signs that only you can notice.

Please see Important Safety Information.

Instead of wondering is that a side effect or not, I get in touch with my doctor and discuss it.

– Actor portrayal

IT’S IMPORTANT TO NOTICE ANY CHANGES IN YOUR BODY AFTER YOU BEGIN TREATMENT AND
TO REPORT THEM TO YOUR HEALTHCARE TEAM RIGHT AWAY.

If you are taking OPDIVO in combination with another medicine, consult your healthcare professional about the potential side effects of that medicine.

Select each body part to learn what to look for.

Discuss the most common side effects of OPDIVO with your doctor. These include: feeling tired; rash; pain in muscles, bones, and joints; itchy skin; diarrhea; nausea; weakness; cough; vomiting; shortness of breath; constipation; decreased appetite; back pain; upper respiratory tract infection; fever; headache; stomach-area (abdominal) pain; and urinary tract infection. There may also be serious side effects, including complications of stem cell transplant that uses donor stem cells (allogeneic). These are not all of the possible side effects of OPDIVO. This is why you need to report any discomfort or changes in the way you are feeling to your Oncology Care Team.

KNOWING THE ANSWERS TO THESE QUESTIONS CAN HELP

Click to watchplay button
 
Video length: 01:40

Please see
Important Safety Information.

SECTION 4 OF 4

HOW YOUR SUPPORT TEAM CAN HELP

Who's on your support team? Watch this video to find out who they can be—and how they can help.

Continue watching this video Learn how people can help you along
the way.

Now that you've completed this
video, remember: You are not alone. Keep your support
team involved and informed so they can
help you throughout your treatment.

If I’ve learned nothing
else…have a team that is going
to support you all the way
through the experience.

– John, OPDIVO patient Patient was compensated for his comments.
SECTION 4 OF 4

HOW YOUR SUPPORT TEAM CAN HELP

Video length: 01:40
Click to watch play button
 

Please see Important Safety Information.

Who's on your support team? Watch this video to find out who they can be—and how they can help.

Continue watching this video Learn how people can help you along
the way.

Now that you've completed this
video, remember: You are not alone. Keep your support
team involved and informed so they can
help you throughout your treatment.

If I’ve learned nothing
else…have a team that is going
to support you all the way
through the experience.

– John, OPDIVO patient Patient was compensated for his comments.

STEP 2REVIEW AND SHARE

Get a completion certificate with a quick
summary of what you've learned. Review the information with your doctor during
your next appointment.

GET IT NOW
PATIENT RESOURCE LIBRARY

Click below to download and print materials to use
while you're on treatment.

SIGN UP FOR INFORMATION AND SUPPORT

Get complimentary support, tools, and
educational resources.

SELECT IMPORTANT FACTS ABOUT OPDIVO

OPDIVO can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include lung problems; intestinal problems; liver problems; hormone gland problems; kidney problems; skin problems; problems in other organs and tissues; severe infusion reactions; and complications of stem cell transplant that uses donor stem cells (allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms.

Important Facts About OPDIVO® (nivolumab)

This is a summary of important information that you need to know about OPDIVO. Your healthcare team can work with you to help answer any questions you may have about OPDIVO. Keep this information in a safe place so you can refer to it before and during your treatment.

Look out for the following icons as you read:

  • Talk to your
    healthcare team
  • Call a healthcare
    provider right away
  • Helpful information
    to remember

What is OPDIVO?

OPDIVO is a prescription medicine used to treat:

 Adults and children 12 years of age and older who have a type of skin cancer called melanoma, and:

Whose melanoma has spread or cannot be removed by surgery (advanced melanoma).

 Adults who have a type of advanced stage lung cancer called non-small cell lung cancer, and who:

Have lung cancer that has spread or grown, AND

Have tried chemotherapy that contains platinum, and it did not work or is no longer working, AND

If their tumor has an abnormal EGFR or ALK gene, they have also tried an FDA-approved therapy for tumors with these abnormal genes and it did not work or is no longer working.

 Adults who have kidney cancer (renal cell carcinoma):

OPDIVO in combination with cabozantinib is approved for adults:

Whose kidney cancer has spread (advanced RCC), AND

Who have not already had treatment for their advanced RCC.

Please read the Patient Information that comes with cabozantinib.

OPDIVO is approved for adults:

Whose kidney cancer (RCC) has spread or grown after treatment with other cancer medicines.

 Adults who have a type of blood cancer called classical Hodgkin lymphoma, and who:

Have classical Hodgkin lymphoma that has come back or spread after a type of stem cell transplant that uses their own stem cells (autologous stem cell transplant), AND

Used the medicine brentuximab vedotin before or after the stem cell transplant, OR

Received at least 3 kinds of treatment including an autologous stem cell transplant.

OPDIVO was approved based on response rate. There is ongoing evaluation of clinical benefit of OPDIVO for this use.

 Adults who have head and neck cancer called squamous cell carcinoma of the head and neck (SCCHN), and who:

Have been treated with chemotherapy that contains platinum, but their head and neck cancer has returned or spread after treatment.

 Adults who have cancer of the lining of the urinary tract (including the bladder, urethra, ureters, or renal pelvis) (urothelial carcinoma).

OPDIVO is approved for adults who have:

Urinary tract cancer that has spread or grown (locally advanced or metastatic), AND

Tried chemotherapy that contains platinum, and it did not work or is no longer working, OR

Cancer that worsened within 12 months of treatment with chemotherapy that contains platinum, either before or after surgery to remove the cancer.

 

OPDIVO is approved to help prevent cancer from coming back in adults who:

Have cancer of the urinary tract (including the bladder, ureters, or renal pelvis), AND

Had surgery to remove the cancer.

 Adults and children 12 years of age and older who have colorectal cancer (a type of colon or rectal cancer), and who:

Have colorectal cancer that has spread to other parts of the body (metastatic), AND

Have a tumor that is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), AND

Have tried treatment with a fluoropyrimidine, oxaliplatin, and irinotecan, and it did not work or is no longer working.

OPDIVO was approved based on response rate and how long patients’ responses lasted. There is ongoing evaluation of clinical benefit of OPDIVO for this use.

 Adults and children 12 years of age and older who have a type of skin cancer called melanoma, and who:

Have had surgery to remove it and lymph nodes that contain cancer, to help prevent melanoma from coming back.

 Adults who have cancer of the tube that connects the throat to the stomach (esophageal cancer) and their cancer:

Is a type called squamous cell carcinoma, AND

Cannot be removed with surgery, or

Has spread to other parts of the body (metastatic), and they have not already had treatment for their advanced or metastatic esophageal cancer.

OPDIVO with chemotherapy that contains fluoropyrimidine and platinum is approved for adults whose esophageal cancer cannot be removed with surgery, has spread to other parts of the body, and who have not already had treatment for their advanced or metastatic esophageal cancer.

 Adults who have cancer of the tube that connects the throat to the stomach (esophageal cancer), and their cancer:

Is a type called squamous cell carcinoma, AND

Cannot be removed with surgery, or

Has come back or spread to other parts of the body (metastatic), and they have already had treatment for their advanced or metastatic esophageal cancer.

OPDIVO alone is approved for adults whose esophageal cancer has come back or spread to other parts of the body after treatment with chemotherapy that contains fluoropyrimidine and platinum.

 Adults who have cancer of the tube that connects the throat to the stomach (esophageal cancer) or cancer where the esophagus joins the stomach (gastroesophageal junction cancer) and who:

Have been treated with chemoradiation, AND THEN

Had surgery to completely remove the cancer, but some cancer cells were still present in the removed tumor or lymph nodes.

OPDIVO may be used to help prevent the esophageal or gastroesophageal junction cancer from coming back.

 Adults who have:

Cancer of the stomach (gastric cancer)

Cancer where the esophagus joins the stomach (gastroesophageal junction cancer), and in adults with

Esophageal adenocarcinoma.

OPDIVO may be used with chemotherapy that contains fluoropyrimidine and platinum in adults whose gastric, gastroesophageal junction, or esophageal cancer:

Cannot be removed with surgery, OR

Has spread to other parts of the body.

It is not known if OPDIVO is safe and effective in children younger than 12 years of age with melanoma or MSI-H or dMMR metastatic colorectal cancer.

It is not known if OPDIVO is safe and effective in children for the treatment of any other cancers.

OPDIVO (10 mg/mL) is an injection for intravenous (IV) use.

What is the most important information I should know about OPDIVO?

OPDIVO is a medicine that may treat certain cancers by working with your immune system. OPDIVO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. Some of these problems may happen more often when OPDIVO is used in combination with another therapy.

Get medical help immediately if you develop any of these signs or symptoms or they get worse. It may keep these problems from becoming more serious. Your healthcare team will check you for these problems during treatment and may treat you with corticosteroid or hormone replacement medicines. If you have severe side effects, your healthcare team may also need to delay or completely stop your treatment.

What are the serious side effects of OPDIVO?

A serious side effect is a side effect that can sometimes become severe or life-threatening and can lead to death. They may happen anytime during treatment or even after your treatment has ended. You may have more than one of these problems at the same time.

Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:

Lung problems – Things to look out for may include:

  • new or worsening cough
  • shortness of breath
  • chest pain

Intestinal problems – Things to look out for may include:

  • diarrhea (loose stools) or more
    frequent bowel movements than usual
  • stools that are black, tarry,
    sticky, or have blood or mucus
  • severe stomach-area (abdominal)
    pain or tenderness

Liver problems – Things to look out for may include:

  • yellowing of your skin or
    the whites of your eyes
  • severe nausea or vomiting
  •  
  •  
  • pain on the right side of your
    stomach area (abdomen)
  • dark urine (tea colored)
  •  
  • bleeding or bruising more easily
    than normal

Hormone gland problems – Things to look out for may include:

  • headaches that will not go away
    or unusual headaches
  • eye sensitivity to light
  • eye problems
  • rapid heartbeat
  • increased sweating
  • extreme tiredness
  • weight gain or weight loss
  • feeling more hungry or thirsty than
    usual
  • urinating more often than usual
  • hair loss
  • feeling cold
  • constipation
  • your voice gets deeper
  • dizziness or fainting
  • changes in mood or behavior,
    such as decreased sex drive,
    irritability, or forgetfulness
  •  
  •  

Kidney problems – Things to look out for may include:

  • decrease in your amount of urine
  • blood in your urine
  • swelling of your ankles
  •  
  •  
  • loss of appetite

Skin problems – Things to look out for may include:

  • rash
  • itching
  • skin blistering or peeling
  •  
  • painful sores or ulcers in the mouth or
    nose, throat, or genital area

Problems can also happen in other organs and tissues. These are not all the signs and symptoms of immune system problems that can happen with OPDIVO. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include:

  • Chest pain, irregular heartbeat,
    shortness of breath, swelling of
    ankles
  •  
  • Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
  • Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
  • Persistent or severe muscle pain
    or weakness, muscle cramps
  • Low red blood cells, bruising

What are the possible side effects of OPDIVO?

OPDIVO can cause serious side effects, including:

See the previous section, “What is the most important information I should know about OPDIVO?”

Severe infusion reactions – Things to look out for may include:

  • chills or shaking
  • itching or rash
  • flushing
  • shortness of breath or wheezing
  • dizziness
  • feel like passing out
  • fever
  • back or neck pain

Tell your healthcare team right away if you get these symptoms during an infusion of OPDIVO.

Complications of bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be severe and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with OPDIVO. Your healthcare provider will monitor you for these complications.

What are the most common side effects of OPDIVO?

The most common side effects of OPDIVO when used alone include:

  • feeling tired
  • rash
  • pain in muscles, bones, and joints
  • itchy skin
  • diarrhea
  •  
  •  
  • nausea
  • weakness
  • cough
  • vomiting
  • shortness of breath
  • constipation
  • decreased appetite
  • back pain
  • upper respiratory tract infection
  • fever
  • headache
  • stomach-area (abdominal) pain
  • urinary tract infection
  •  

The most common side effects of OPDIVO when used in combination with cabozantinib include:

  • diarrhea
  • feeling tired or weak
  • liver problems
  • rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
  • mouth sores
  • rash
  • high blood pressure
  • low thyroid hormone levels
  • pain in muscles, bones, and joints
  •  
  • decreased appetite
  • nausea
  • change in the sense of taste
  • stomach-area (abdominal) pain
  • cough
  • upper respiratory tract infection

The most common side effects of OPDIVO when used in combination with fluoropyrimidine and platinum-containing chemotherapy include:

  • nausea
  • numbness, pain, tingling, or burning in your hands or feet
  •  
  • decreased appetite
  • feeling tired
  • constipation
  • mouth sores
  • diarrhea
  • vomiting
  • stomach-area (abdominal) pain
  • pain in muscles, bones, and joints

These are not all the possible side effects. Talk to your healthcare team or pharmacist for more information. You are encouraged to report side effects of prescription drugs to the FDA. Call 1-800-FDA-1088.

What should I discuss with my healthcare team before receiving OPDIVO?

Tell your healthcare provider about all your medical conditions, including if you:

  • have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • have received an organ transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area in the past and have received other medicines that are like OPDIVO
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. OPDIVO can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if OPDIVO passes into your breast milk. Do not breastfeed during treatment and for 5 months after your last dose of OPDIVO.

Females who are able to become pregnant:

Your healthcare provider should do a pregnancy test before you start receiving OPDIVO.

  • You should use an effective method of birth control during your treatment and for 5 months after your last dose of OPDIVO. Talk to your healthcare provider about birth control methods that you can use during this time.
  • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with OPDIVO.

Tell your healthcare provider about all the medicines you take, including:

  • prescription medicines
  • over-the-counter medicines
  • herbal supplements

For more information, please see U.S. Full Prescribing Information and Medication Guide for OPDIVO, or talk to your healthcare team.

Information provided on this website is not a substitute for talking with your healthcare professional.

Your healthcare professional is the best source of information about your disease.

Bristol-Myers Squibb Corporate Site

Legal Notice | Privacy Policy

© 2023 Bristol-Myers Squibb Company.

OPDIVO®, Immuno-Oncology Teach™, and the related logos are trademarks of Bristol-Myers Squibb Company.

Adcetris® is a registered trademark of Seattle Genetics, Inc.

Nexavar® is a registered trademark of Bayer.

1506-US-2300133  04/23