BACK

Now that you and your doctor have chosen
OPDIVO + YERVOY combination immunotherapy

treatment, it's time to set yourself up with information
and support to help you make the most of it.
Use the
resources in this online learning center to get started.

STEP 1WATCH AND
LEARN

Look through the 4 sections below with your family or a friend.

STEP 2REVIEW AND
SHARE

Then, download a summary sheet to go over with your doctor.

STEP 1WATCH AND LEARN

Click to watchplay button
 
Video length: 01:59

Please see
Important Safety Information.

SECTION 1 OF 4

CANCER AND YOUR IMMUNE SYSTEM

Watch this video to learn how your immune system helps your body defend itself against cancer.

Continue watching this video Learning about the immune system will
give you a strong start toward
understanding how immunotherapy may
work.

Now that you've completed this
video, remember: T cells in your immune system normally search for and attack threats like cancer.
Now, watch the next video to learn how OPDIVO + YERVOY may work with
these cells.

STEP 1WATCH AND LEARN

SECTION 1 OF 4

CANCER AND YOUR IMMUNE SYSTEM

Video length: 01:59
Click to watchplay button
 

Please see Important Safety Information.

Watch this video to learn how your immune system helps your body defend itself against cancer.

Continue watching this video Learning about the immune system will give
you a strong start toward understanding
how immunotherapy may
work.

Now that you've completed this
video, remember: T cells in your immune system normally search for and attack threats like cancer.
Now, watch the next video to learn how OPDIVO + YERVOY may work with these
cells.

Click to watchplay button
 
Video length: 02:08

Please see
Important Safety Information.

SECTION 2 OF 4

HOW OPDIVO + YERVOY COMBINATION IMMUNOTHERAPY WORKS

Watch this video to see how each medicine may
work differently with your immune system—and how
combining these medications may help them do
even more to fight cancer.

Continue watching this video Learn how OPDIVO and YERVOY may
work together to help fight cancer.

Now that you've completed this
video, remember: OPDIVO + YERVOY combines two
medicines that work in different but
complementary ways to help fight cancer.
Now, you're ready to move on to the next
section to learn about side effects.

It is important to know that while helping your T cells attack cancer cells, the OPDIVO + YERVOY combination
therapy could also cause your active T cells to attack healthy cells in your body, and this could lead to side effects.
These problems can sometimes become serious or life-threatening and can lead to death. These problems may
happen anytime during treatment or even after your treatment has ended. Some of these problems may happen
more often when OPDIVO is used in combination with YERVOY.

SELECT IMPORTANT FACTS ABOUT OPDIVO AND YERVOY

OPDIVO and YERVOY can cause problems that can sometimes become serious or life-threatening and can lead to
death. Serious side effects may include lung problems; intestinal problems; liver problems; hormone gland problems;
kidney problems; skin problems; eye problems; problems in other organs and tissues; severe infusion reactions; and
complications of stem cell transplant, including graft-versus-host disease (GVHD), that uses donor stem cells
(allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms.

SECTION 2 OF 4

HOW OPDIVO + YERVOY COMBINATION IMMUNOTHERAPY WORKS

Video length: 02:08
Click to watchplay button
 

Please see Important Safety Information.

Watch this video to see how each medicine may work differently with your immune system—and how combining these medications may help them do even more to fight cancer.

Continue watching this video Learn how OPDIVO and YERVOY may
work together to help fight cancer.

Now that you've completed this
video, remember: OPDIVO + YERVOY combines two
medicines that work in different but
complementary ways to help fight cancer.
Now, you're ready to move on to the next
section to learn about side effects.

It is important to know that while helping your T cells attack cancer cells, the OPDIVO + YERVOY combination therapy could also cause your active T cells to attack healthy cells in your body, and this could lead to side effects. These problems can sometimes become serious or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment has ended. Some of these problems may happen more often when OPDIVO is used in combination with YERVOY.

SELECT IMPORTANT FACTS ABOUT OPDIVO AND YERVOY

OPDIVO and YERVOY can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include lung problems; intestinal problems; liver problems; hormone gland problems; kidney problems; skin problems; eye problems; problems in other organs and tissues; severe infusion reactions; and complications of stem cell transplant, including graft-versus-host disease (GVHD), that uses donor stem cells (allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms.

My doctor was very clear. If there
are any side effects, let him
know right away.

– Dave, OPDIVO + YERVOY patient Patient was compensated for his comments.
SECTION 3 OF 4

SIDE EFFECTS TO LOOK OUT
FOR AND WHAT TO DO

Learn how to play an active role in identifying
and reporting side effects. After all, there may be signs that only you can notice.

 

Please see Important Safety Information.

IT’S IMPORTANT TO NOTICE ANY CHANGES IN YOUR BODY AFTER YOU BEGIN TREATMENT AND
TO REPORT THEM TO YOUR HEALTHCARE TEAM RIGHT AWAY.

If you are taking OPDIVO in combination with another medicine, consult your healthcare
professional about the potential side effects of that medicine.

Select each body part to learn what to look for.

Discuss the most common side effects of OPDIVO + YERVOY with your doctor. These include: feeling tired; rash; pain in muscles, bones, and joints; itchy skin; diarrhea; nausea; weakness; cough; vomiting; shortness of breath; constipation; decreased appetite; back pain; upper respiratory tract infection; fever; headache; stomach-area (abdominal) pain; low thyroid hormone levels (hypothyroidism); decreased weight; and dizziness. There may also be serious side effects, including complications of bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications, such as graft-versus-host disease (GVHD), can be severe and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with OPDIVO or YERVOY. Your healthcare provider will monitor you for these complications. These are not all of the possible side effects of OPDIVO + YERVOY. This is why you need to report any discomfort or changes in the way you are feeling to your Oncology Care Team.

KNOWING THE ANSWERS TO THESE QUESTIONS CAN HELP

SECTION 3 OF 4

SIDE EFFECTS TO LOOK OUT
FOR AND WHAT TO DO

Learn how to play an active role in identifying and reporting side effects. After all, there may be signs that only you can notice.

Please see Important Safety Information.

My doctor was very clear. If there are any side effects, let him know right away.

– Dave, OPDIVO + YERVOY patient Patient was compensated for his comments.

IT’S IMPORTANT TO NOTICE ANY CHANGES IN YOUR BODY AFTER YOU BEGIN TREATMENT AND
TO REPORT THEM TO YOUR HEALTHCARE TEAM RIGHT AWAY.

If you are taking OPDIVO in combination with another medicine, consult your healthcare
professional about the potential side effects of that medicine.

Select each body part to learn what to look for.

Discuss the most common side effects of OPDIVO + YERVOY with your doctor. These include: feeling tired; rash; pain in muscles, bones, and joints; itchy skin; diarrhea; nausea; weakness; cough; vomiting; shortness of breath; constipation; decreased appetite; back pain; upper respiratory tract infection; fever; headache; stomach-area (abdominal) pain; low thyroid hormone levels (hypothyroidism); decreased weight; and dizziness. There may also be serious side effects, including complications of bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications, such as graft-versus-host disease (GVHD), can be severe and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with OPDIVO or YERVOY. Your healthcare provider will monitor you for these complications. These are not all of the possible side effects of OPDIVO + YERVOY. This is why you need to report any discomfort or changes in the way you are feeling to your Oncology Care Team.

KNOWING THE ANSWERS TO THESE QUESTIONS CAN HELP

Click to watchplay button
 
Video length: 01:56

Please see
Important Safety Information.

SECTION 4 OF 4

HOW YOUR SUPPORT TEAM CAN HELP

Who’s on your support team? Watch this video to
find out who they can be—and how they can help.

Continue watching this video Learn how people can help you along
the way.

Now that you've completed this
video, remember: You are not alone. Keep your support
team involved and informed so they can
help you throughout your treatment.

You really need to be your own
advocate and surround yourself
with people who are positive.

– Carol, OPDIVO + YERVOY patient Patient was compensated for her comments.
SECTION 4 OF 4

HOW YOUR SUPPORT TEAM CAN HELP

Video length: 02:01
Click to watchplay button
 

Please see Important Safety Information.

Who’s on your support team? Watch this video to
find out who they can be—and how they can help.

Continue watching this video Learn how people can help you along
the way.

Now that you've completed this
video, remember: You are not alone. Keep your support
team involved and informed so they can
help you throughout your treatment.

You really need to be your own advocate and surround yourself with people who are positive.

– Carol, OPDIVO + YERVOY patient Patient was compensated for her comments.

STEP 2REVIEW AND SHARE

Get a completion certificate with a quick
summary of what you've learned. Review the information
with your doctor during your next appointment.

GET IT NOW
PATIENT RESOURCE LIBRARY

Click below to download and print materials to use
while you're on treatment.

SIGN UP FOR INFORMATION AND SUPPORT

Get complimentary support, tools, and
educational resources.

SELECT IMPORTANT FACTS ABOUT OPDIVO AND YERVOY

OPDIVO and YERVOY can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include lung problems; intestinal problems; liver problems; hormone gland problems; kidney problems; skin problems; eye problems; problems in other organs and tissues; severe infusion reactions; and complications of stem cell transplant, including graft-versus-host disease (GVHD), that uses donor stem cells (allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms.

Important Facts About OPDIVO® (nivolumab) and OPDIVO + YERVOY® (ipilimumab)

This is a summary of important information that you need to know about OPDIVO and OPDIVO + YERVOY. Your healthcare team can work with you to help answer any questions you may have about these medications. Keep this information in a safe place so you can refer to it before and during your treatment.

Look out for the following icons as you read:

  • Talk to your
    healthcare team
  • Call a healthcare
    provider right away
  • Helpful information
    to remember

What is OPDIVO + YERVOY?

OPDIVO is a prescription medicine used in combination with YERVOY (OPDIVO + YERVOY) to treat a type of skin cancer called melanoma. OPDIVO + YERVOY is for adults and children 12 years of age and older:

Whose melanoma has spread or cannot be removed by surgery (advanced melanoma).

OPDIVO is a prescription medicine used in combination with YERVOY (OPDIVO + YERVOY) to treat a type of advanced stage lung cancer called non-small cell lung cancer (NSCLC). OPDIVO + YERVOY is approved as a first treatment for adults:

Who have lung cancer that has spread to other parts of the body (metastatic), AND

Whose tumors are positive for PD-L1 but do not have an abnormal EGFR or ALK gene.

OPDIVO is a prescription medicine used in combination with YERVOY and 2 cycles of chemotherapy that contains platinum and another chemotherapy medicine (OPDIVO + YERVOY + chemo) to treat a type of advanced stage lung cancer called non-small cell lung cancer (NSCLC). OPDIVO + YERVOY + chemo is approved as a first treatment for adults:

Who have lung cancer that has spread or grown (metastatic) or comes back (recurrent), AND

Whose tumors do not have an abnormal EGFR or ALK gene.

OPDIVO is a prescription medicine used in combination with YERVOY (OPDIVO + YERVOY) to treat a type of cancer called malignant pleural mesothelioma, which affects the lining of the lungs and chest wall. OPDIVO + YERVOY is approved as a first treatment for adults with malignant pleural mesothelioma that cannot be removed by surgery.

OPDIVO is a prescription medicine used in combination with YERVOY (OPDIVO + YERVOY) to treat kidney cancer (renal cell carcinoma) in certain adults:

Whose kidney cancer has spread (advanced RCC), AND

Who have not already had treatment for their advanced RCC.

OPDIVO is a prescription medicine used in combination with YERVOY (OPDIVO + YERVOY) to treat colorectal cancer (a type of colon or rectal cancer). OPDIVO + YERVOY is for adults and children 12 years of age and older who:

Have colorectal cancer that has spread to other parts of the body (metastatic), AND

Have a tumor that is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), AND

Have tried treatment with a fluoropyrimidine, oxaliplatin, and irinotecan, and it did not work or is no longer working.

OPDIVO + YERVOY was approved based on response rate and how long patients’ responses lasted. There is ongoing evaluation of clinical benefit of OPDIVO + YERVOY for this use.

OPDIVO is a prescription medicine used in combination with YERVOY (OPDIVO + YERVOY) to treat liver cancer (hepatocellular carcinoma). OPDIVO + YERVOY is for adults who:

Have previously received treatment with sorafenib.

OPDIVO + YERVOY was approved based on response rate and how long patients’ responses lasted. There is ongoing evaluation of clinical benefit of OPDIVO + YERVOY for this use.

OPDIVO is a prescription medicine used in combination with YERVOY to treat adults with cancer of the tube that connects the throat to the stomach (esophageal cancer) and their cancer:

Is a type called squamous cell carcinoma, AND

Cannot be removed with surgery (advanced), OR

Has spread to other parts of the body (metastatic), AND

They have not already had treatment for their advanced or metastatic esophageal cancer.

It is not known if OPDIVO is safe and effective in children younger than 12 years of age with melanoma or MSI-H or dMMR metastatic colorectal cancer.

It is not known if OPDIVO is safe and effective in children for the treatment of any other cancers.

What is the most important information I should know about OPDIVO + YERVOY?

OPDIVO and YERVOY are medicines that may treat certain cancers by working with your immune system. OPDIVO and YERVOY can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. Some of these problems may happen more often when OPDIVO is used in combination with another therapy.

Get medical help immediately if you develop any of these signs or symptoms or they get worse. It may keep these problems from becoming more serious. Your healthcare team will check you for these problems during treatment and may treat you with corticosteroid or hormone replacement medicines. If you have severe side effects, your healthcare team may also need to delay or completely stop your treatment.

What are the serious side effects of OPDIVO + YERVOY?

A serious side effect is a side effect that can sometimes become severe or life-threatening and can lead to death. They may happen anytime during treatment or even after your treatment has ended. You may have more than one of these problems at the same time.

Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:

Lung problems — Things to look out for may include:

  • new or worsening cough
  • shortness of breath
  • chest pain

Intestinal problems — Things to look out for may include:

  • diarrhea (loose stools) or more
    frequent bowel movements than usual
  • stools that are black, tarry,
    sticky, or have blood or mucus
  • severe stomach-area
    (abdominal) pain or tenderness

Liver problems — Things to look out for may include:

  • yellowing of your skin or the
    whites of your eyes
  • severe nausea or vomiting
  •  
  • pain on the right side of your
    stomach area (abdomen)
  • dark urine (tea colored)
  • bleeding or bruising more easily
    than normal

Hormone gland problems — Things to look out for may include:

  • headaches that will not go
    away or unusual headaches
  • eye sensitivity to light
  • eye problems
  • rapid heartbeat
  • increased sweating
  • extreme tiredness
  • weight gain or weight loss
  • feeling more hungry or thirsty than usual
  • urinating more often than usual
  • hair loss
  • feeling cold
  • constipation
  • your voice gets deeper
  • dizziness or fainting
  • changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

Kidney problems — Things to look out for may include:

  • decrease in your amount of urine
  • blood in your urine
  • swelling of your ankles
  •  
  • loss of appetite

Skin problems — Things to look out for may include:

  • rash
  • itching
  • skin blistering or peeling
  •  
  • painful sores or ulcers in the mouth
    or nose, throat, or genital area

Eye problems — Things to look out for may include:

  • blurry vision, double vision, or
    other vision problems
  • eye pain or redness
  •   
  •   

Problems can also happen in other organs and tissues. These are not all the signs and symptoms of immune system problems that can happen with OPDIVO and YERVOY. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include:

  • Chest pain, irregular heartbeat, shortness of breath, swelling of ankles
  • Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
  • Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
  • Persistent or severe muscle pain or weakness, muscle cramps
  • Low red blood cells, bruising

What are the possible side effects of OPDIVO + YERVOY?

OPDIVO + YERVOY can cause serious side effects, including:

See the previous section, “What is the most important information I should know about OPDIVO + YERVOY?”

Severe infusion reactions — Things to look out for may include:

  • chills or shaking
  • itching or rash
  • flushing
  • shortness of breath or wheezing
  • dizziness
  • feel like passing out
  •   
  • fever
  • back or neck pain

Tell your healthcare team right away if you get these symptoms during an infusion of OPDIVO or YERVOY.

Complications, including graft-versus-host disease (GVHD), of bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be severe and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with OPDIVO or YERVOY. Your healthcare provider will monitor you for these complications.

What are the most common side effects?

The most common side effects of OPDIVO when used in combination with YERVOY include:

  • feeling tired
  • diarrhea
  • rash
  • itching
  • nausea
  • pain in muscles, bones, and joints
  • fever
  • cough
  • decreased appetite
  • vomiting
  • stomach-area (abdominal) pain
  • shortness of breath
  • upper respiratory tract infection
  • headache
  • low thyroid hormone levels (hypothyroidism)
  • constipation
  • decreased weight
  • dizziness

The most common side effects of OPDIVO when used in combination with YERVOY and chemotherapy include:

  • feeling tired
  • pain in muscles, bones, and joints
  • nausea
  • diarrhea
  • rash
  • decreased appetite
  • constipation
  • itching

The most common side effects of OPDIVO when used in combination with chemotherapy include:

  • nausea
  • constipation
  • feeling tired
  • decreased appetite
  • rash

These are not all the possible side effects. Talk to your healthcare team or pharmacist for more information. You are encouraged to report side effects of prescription drugs to the FDA. Call 1-800-FDA-1088.

What should I discuss with my healthcare team before receiving OPDIVO or YERVOY?

Tell your healthcare provider about all your medical conditions, including if you:

  • have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • have received an organ transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area in the past and have received other medicines that are like OPDIVO
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. OPDIVO and YERVOY can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if OPDIVO or YERVOY passes into your breast milk. Do not breastfeed during treatment and for 5 months after your last dose of OPDIVO or YERVOY.

Females who are able to become pregnant:

Your healthcare provider should do a pregnancy test before you start receiving OPDIVO or YERVOY.

  • You should use an effective method of birth control during your treatment and for 5 months after the last dose of OPDIVO or YERVOY. Talk to your healthcare provider about birth control methods that you can use during this time.
  • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with OPDIVO or YERVOY. You or your healthcare provider should contact Bristol Myers Squibb at 1-844-593-7869 as soon as you become aware of a pregnancy.

Tell your healthcare provider about all the medicines you take, including:

  • prescription medicines
  • over-the-counter medicines
  • vitamins
  • herbal supplements

For more information, please see U.S. Full Prescribing Information and Medication Guide for YERVOY.

For more information, please see U.S. Full Prescribing Information and Medication Guide for OPDIVO.

Talk to your healthcare team for more information about these medications.

Information provided on this website is not a substitute for talking with your healthcare professional.
Your healthcare professional is the best source of information about your disease.

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© 2023 Bristol-Myers Squibb Company.

OPDIVO®, YERVOY®, Immuno-Oncology TeachTM, and the related logos are trademarks of Bristol-Myers Squibb Company.

All other trademarks listed are the property of their respective owners.

7356-US-2300172  04/23